The p53-mdm-2 autoregulatory feedback loop.
نویسندگان
چکیده
منابع مشابه
A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation
p53-Transcriptional-regulated proteins interact with a large number of other signal transduction pathways in the cell, and a number of positive and negative autoregulatory feedback loops act upon the p53 response. P53 directly controls the POMC/α-MSH productions induced by ultraviolet (UV) and is associated with UV-independent pathological pigmentation. When identifying the causative gene of dy...
متن کاملSupplementary information for “ Stress - specific response of the p 53 - Mdm 2 feedback loop ”
Parameter values There are 9 parameters in these equations. Some can be fixed or constrained using data from literature: 1. p53 does not measurably degrade over 120 min in the absence of Mdm2 [1]. Therefore, its Mdm2independent degradation rate, α, is very low. We took α = 0.1hr, corresponding to a half life of 7.5 hours. In any case, as shown in Fig. 3 of the main text, varying α by upto 5-fol...
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The p53 network is perhaps the most important pathway involved in preventing the initiation of cancer, p53 levels and activity are upregulated in response to various stresses including DNA damage, hypoxia, and oncogene activation. Active p53 initiates different transcriptional programs that result in cell cycle arrest, cellular senescence or apoptosis. p53 also activates the transcription of Md...
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Tumor suppressor p53 and its signaling pathway play a central role in tumor prevention. The E3 ubiquitin ligase MDM2, which is a direct p53 transcriptional target and also the most critical negative regulator of p53, forms an autoregulatory negative feedback loop with p53 in the cell to tightly regulate the levels and activity of p53. MicroRNAs (miRNAs) are endogenously expressed small non-codi...
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A key circuit in the response of cells to damage is the p53-mdm2 feedback loop. This circuit shows sustained, noisy oscillations in individual human cells following DNA breaks. Here, we apply an engineering approach known as systems identification to quantify the in vivo interactions in the circuit on the basis of accurate measurements of its power spectrum. We obtained oscillation time courses...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1993
ISSN: 0890-9369
DOI: 10.1101/gad.7.7a.1126